![]() Almost all analysis modules output an interactive HTML report summarizing results, in addition to detailed tables and plots.įigure 1. Panoply org series#Analysis ready data is then channelled to a series of Data Analysis Modules, many of which perform integrated multi-omic analysis. Any normalization or filtering for proteomics data is accomplished using Data Preparation Modules. PANOPLY takes as input a set of pre-formatted datasets derived from DNA, RNA and protein profiling, along with phenotype and clinical annotations (see Figure 1). PANOPLY combines representative methods from these studies, which originated as disparate algorithms implemented by different research groups, into a unified pipeline within a computational framework built to be modular, scalable and reproducible. These flagship studies have advanced the field by developing cutting-edge computational methods. Proteogenomic analysis has been extensively applied to cancer samples in many studies published under the auspices of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the International Cancer Proteogenome Consortium (ICPC), a global effort to accelerate the understanding of the molecular basis of cancer through the application of proteogenomics. We wanted researchers to be able to use it on any standard computational platform, so we designed PANOPLY to be modular and portable, but we chose to also make it available through Terra to increase access, scalability and ease of use.Ī “greatest hits” compilation of methods from flagship CPTAC studies We decided to address this problem by building a framework called PANOPLY that would streamline analysis of proteogenomics data and would be easy to use, robust, flexible and reproducible. Effectively analyzing proteogenomics data involves deploying complex computational algorithms that integrate multiple omics data types, and unfortunately, such algorithms remain largely inaccessible to non-computational cancer researchers. Proteogenomics involves the integrative analysis of genomic, transcriptomic, proteomic and post-translational modification (PTM) data produced by next-generation sequencing and mass spectrometry-based proteomics. Mani, principal computational scientist in the Broad Institute’s Proteomics Platform and lead author of the recently published PANOPLY paper, explains how his team is leveraging Terra to make PANOPLY accessible to a wide range of researchers. The Storyboard Terminology Sheet may be useful to help.PANOPLY is an innovative computational framework for applying state-of-the-art statistical and machine learning algorithms to transform multi-omic data from cancer samples into biologically meaningful and interpretable results. The Symposion Storyboard Sheet can be used to challenge your pupils to plan a new animation based on this vase. The Symposion Drawing Worksheet has a blank space for symposion guests and a blank space in the middle for a new gorgon face. More information can be found on the Panoply Vase Animation Project website On Symposiums and Vases: A Panoply Interview marking the creation of The Symposion with Prof Sir John Boardman (Senior Research Associate at the Classical Art Research Centre in Oxford and Emeritus Lincoln Professor of Classical Archaeology and Art). Such cups were used at Ancient Greek ancient drinking parties. 500 BC, currently in the Ashmolean Museum of the University of Oxford. The cup featured in The Symposion is an Athenian black-figure footed cup ( kylix) made c. From Chiusi, Italy and currently in the Museo Archeologico Regionale at Palermo. Tondo of an Attic red-figure kylix (480-460 BC) depicting a young man playing kottabos. This animation depicts a popular game called kottabos, in which people competed in flinging the sediment (lees) from their wine-cup at a target. Many of the evening’s activities would be arranged as competitions, whether it was debating, telling jokes and riddles, performing music, or playing games. Like many things in ancient Greek culture, symposia had a competitive aspect. It was their responsibility to set the tone of the evening and, in theory, to see that everyone behaved properly. A symposiarch, or symposium leader, presided over the evening, pouring offerings for Dionysus, regulating the drinking, and managing the activities. The guests might have had dinner together beforehand. Guests usually reclined on couches facing towards each other and used a range of vases to mix, serve, and drink watered wine. Panoply org professional#Non-citizen men, and women who were professional entertainers or companions, might also attend. At symposia, groups of adult citizens gathered to enjoy each other’s company or to celebrate special occasions. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |